Beauty Tips for charming skin

• The most important of all is to be happy all the time
• Never be tense from ups and downs of life
• Wake up early and do excercise
• Use sun block when go outside whether in winter or summer
• Make habit of Cleansing daily with quality cleanser
• Use Moisturizer two or three times a day
• Eat raw vegetables and fruits
• Eat egg in breakfast
• Drink water and fresh juice
• Yoga
  

Take advantage of summer’s extra leisure time to improve your memory with these new brain tricks:
1. Warm up to a new sport A recent study from Columbia University Medical Center links blood glucose levels that rise as we age to memory lapses. Try a fun summer sport, like beach volleyball or swimming, to help your body regulate blood sugar.
2. Grab a page-turner New research from the Mayo Clinic shows that reading decreases your risk of developing mild memory loss by 30 to 50 percent, so don’t forget to toss a great book in your beach bag. A few to check out: Jodi Picoult’s new novel, Handle With Care (Atria, 2009; $27.95), A Fortunate Age by Joanna Smith Rakoff (Scribner, 2009; $26), or Love or Something Like It by Deirdre Shaw (Random House, 2009; $22).
3. Order the iced coffee Chill with three cups of caffeinated java a day and you could lower your risk of developing dementia by up to 70 percent, according to a study from the Journal of Alzheimer’s Disease.

Sick to quit Drinking

PREPARE YOURSELF TO QUIT DRINKING:
1. Do not go with the friends who used to drink! Remember, you're not being forced to give up a good friend who has treated you well. Instead, you are finally ridding yourself of an awful enemy who has robbed you of many great pleasures in life.

2. Constantly remind yourself of what a great thing you are doing and hold tightly to your quit. Remember that you are pardoning yourself from a life sentence in the prison of alcoholism and you will always hold the key.
3. Try to pick some significant date to quit. Be ambitious, but reasonable. If you are very heavy drinker you must first slow down to avoid withdraws (in this case it is best to have your doctor help you plan your quit date).
4. Get rid of all bottles, cans, etc.
5. Revise recipes that call for wine so you do not have it in the kitchen.
6. Buy a wallet and whenever you think about buying a bottle or a drink, put that amount of money in your sober wallet. It will shock you. Use this for healthier stress relief: massage, visit to a day spa, yoga class...
7. Buy a small piece of inexpensive jewelry like a ring or bracelet, or henna your hand, or get a special manicure to remind you that these hands no longer buy or touch alcohol.
8. Drink a lot of water.
9. Consider joining a support group like Alcoholics Anonymous. These groups have helped millions of people to quit. There are also secular support groups as well such as SMART Recovery.

10. Never take another sip.
11. Deny yourself nothing except the alcohol - You can have anything you want, as long as it's not alcohol (so long as you're not replacing the alcohol with another addiction).
12. Don't try to explain quitting or trying to quit to people -- if they themselves are not in this situation, they are unable to fathom what you're trying to do. Many people will try to enable you and convince you to drink so they can feel better about their own addiction.
13. Admit to yourself, and remember it, that there is absolutely nothing in your life more important than this one thing.
14. Do not avoid all situations where you would normally drink. Instead approach them with a good attitude and remember that you can have a good time without drinking.
15. Memorize a prayer, poem or something (i.e. Hamlet's speech "To be or not to be") to repeat to yourself when you are losing your mind; trying to remember it will keep your head together sometimes.
16. Give yourself a prize for every day or every hour that you haven't had a drink.
17. Talk to your doctor. Alcohol withdrawal can potentially be deadly. If you start experiencing severe hallucinations, you should check into a hospital or treatment center.
18. "He who conquers others is mighty. He who conquers himself is almighty."
19. Take a B-vitamin supplement daily for your first week off alcohol. Alcohol affects the ability of the body to absorb these (specifically thiamine). Deficiency can cause severe cognitive impairment (Wernicke-Korsakoff syndrome or wet brain).
20. If you are tempted, try to visualize what you might look like totally out of control. Do you really want to be that person again?
21. If you are a scheduled drinker, like after work or when you go home, change your routine to involve another activity like visiting your parents or a friend.

22. Try to make yourself busy all the time work.

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Protease Inhibitors And Cancer

Somebody should give a shout out to Dr. Troll of New York
University .. who FIRST .. discovered these as reported by .. me ..
many years .. ago ..
I believe it is .. niacin .. a natural protease inhibitor ..
Dr. Troll must be a .. scientologist ..

UCSF researchers identify new drug target for Kaposi's sarcoma
Science Centric | 30 July 2009 16:09 GMT

UCSF researchers have identified a new potential drug target for the
herpes virus that causes Kaposi's sarcoma, re-opening the possibility
of using the class of drugs called protease inhibitors against the
full herpes family of viruses, which for 20 years has been deemed too
difficult to attain.

The new drug target, which is known as a protease dimer, could serve
as a model for developing new therapeutics for diseases ranging from
cancer to Alzheimer's, the researchers say. Findings are reported in
the Advance Online Publication section of the 'Nature Chemical
Biology' web site.

Most current antiviral drugs target the active sites of viral
proteins, where enzymes and receptors work in a lock-and-key approach
to either activate or deactivate that particular protein, the
researchers explained. Traditionally, drug development has focused on
inhibiting that lock-and-key action to prevent the enzyme, or receptor
from being effective.

Some viral enzymes known as proteases, however, including those for
HIV and the herpes virus family, take the form of a dimer, or two
identical halves - much like a fully opened clamshell - in their most
stable state. Those proteases play an essential role in making the
virus infectious, but require the two clamshell halves to bind
together to be activated, according to the paper.

The HIV protease was successfully targeted for drug development in the
1980s, by blocking the active site on the surface of the dimer, but
the herpes virus protease dimer has consistently eluded efforts to
disrupt it at its active site, the researchers said.

The UCSF team set out to find ways to instead prevent the two halves
of the dimer from connecting at that clamshell joint, to prevent it
from activating. What they found was a new target on the unstable,
monomer form of the protease, which responded well to a chemical
inhibitor.

'If you disrupt the protein-protein interactions, you don't need the
key to a specific lock,' said Charles S. Craik, PhD, senior author on
the paper and a professor of pharmaceutical chemistry in the UCSF
School of Pharmacy. 'Instead, we're essentially preventing the lock
from being made in the first place.'

Craik, who also led a team that identified HIV protease inhibitors in
the late 1980s, said the 'Nature Chemical Biology' paper validates
this new site as a viable option for small-molecule drugs to treat
Kaposi's, as well as other members of this viral family.

'All known herpes virus proteases are structurally similar,' Craik
explained. 'The inhibitor we found knocks out not only KS, but also
the cytomegalovirus protease, so the site we've identified here could
be a target for a broad-acting inhibitor against the entire viral
family.'

To their knowledge, the researchers said, this is the first small-
molecule inhibitor of a herpes virus protease to not only act outside
the active site, but also to select for the partially unfolded protein
to keep it from forming the dimer interface.

Herpes viruses make up one of the most prevalent viral families,
including eight human viruses that cause a variety of devastating
illnesses, the researchers said. Those include mononucleosis (Epstein-
Barr virus), shingles (Varicella zoster virus), genital herpes (herpes
simplex), retinitis (cytomegalovirus) and cancer (Kaposi's sarcoma).
While therapies exist for these viruses, they often have negative side
effects and are facing rising viral resistance.

In addition to validating herpes virus proteases as suitable targets,
Craik said this research was also among the first to use computational
design to identify and create a potential drug to target that protease
interface.

Using high-throughput screening, the team screened a library of 182
compounds that it had specifically and rationally designed to mimic
the protease interface. The work identified six molecules that
inhibited the Kaposi's sarcoma virus protease activity by at least 50
percent, including one that was highly potent.

That discovery potentially opens myriad opportunities for drug
discovery, Craik said, by making target receptors that were
biologically validated, but then deemed undruggable, more attractive.
Protein-protein interactions have been researched as drug targets
against a range of diseases, from certain cancers to neurodegenerative
diseases. This advance could enable researchers to reconsider those
targets, he said.